Glycolysis / Gluconeogenesis
| PAG Title | Glycolysis / Gluconeogenesis |
| PAG ID | WIG000527 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module , which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,238 |
| Information Content | Rich |
| Other IDs | M11521 |
| Base PAG ID | WIG000527 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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